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The potency of GLP-1 RA after Fc fusion is another concern, as linking the GLP-1 analog with the IgG1 hinge region directly results in a severe loss of potency, suggesting a suitable spacer is needed for potency retention [86]

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[11] [1] In some participants, liver fat was reduced to below the 5% threshold conventionally used to define hepatic steatosis, suggesting potential resolution of fatty liver in those individuals